Nicotinic acid is a type of vitamin that can be used to make NAD+, a molecule that helps cells produce energy. NAD+ is made from nicotinic acid in three steps, which are called the Preiss-Handler pathway. Here is a basic explanation of how it works:
1. Nicotinic acid reacts with a sugar molecule called PRPP and then changes nicotinic acid into NAMN.
2. NAMN into NAAD
3. NAAD into NAD+.
NAD+ is now ready to be used by the cell for various processes, such as breaking down food into energy or repairing DNA damage. NAD+ is a coenzyme that is involved in redox reactions, which means it transfers electrons from one molecule to another. This is how it carries energy inside the cells.
When first beginning to take GPR109A supplement, the niacin causes a temporary flushing effect as free radicals and inflammation are being exfoliated from your body. Flushing happens when nicotinic acid activates a receptor called GPR109A, which is found on some cells in the skin and other tissues. GPR109A is a protein that can send signals inside the cell when it binds to nicotinic acid or other molecules. When GPR109A is activated in the skin, it triggers the release of substances that make the blood vessels widen and increase blood flow. This causes the skin to become hot and red. Flushing is deemed harmless, but it can be uncomfortable until acclimated.
Niacin: Niacin is a B vitamin that is converted to NAD+ in the body. NAD+ is a coenzyme that is involved in many cellular processes, including energy production. When NAD+ levels are high, cells are able to produce more energy. Niacin can also help to activate GPR109A directly.
When first beginning to take GPR109A supplement, the niacin causes a temporary flushing effect as free radicals and inflammation are being exfoliated from your body.
* This product is not intended to diagnose, treat, cure or prevent any disease.
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